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Article

Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target.

Journal of the American College of Surgeons - 1 May 2009

Witkiewicz Agnieszka K, Costantino Christina L, Metz Richard, Muller Alexander J, Prendergast George C, Yeo Charles J, Brody Jonathan R

Abstract excerpt

BACKGROUND: The recently discovered indoleamine 2,3-dioxygenase-2 (IDO2) gene has 2 functional polymorphisms that abolish its enzymatic activity. We hypothesize that expression of the IDO2 enzyme in primary pancreatic ductal adenocarcinomas (PDA) can help cancer cells evade immune detection. STUDY DESIGN: Because the IDO2 enzyme might be the preferential target of d-1-methyl-tryptophan, a clinical lead inhibitor...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Indoleamine-Pyrrole 2,3,-Dioxygenase

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Source

Open in PubMed Open full text

Identifiers

PMID: 19476837
DOI: 10.1016/j.jamcollsurg.2008.12.018
PMCID: PMC3176891

Genes

IDO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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