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Article

Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders.

Journal of autoimmunity - 1 Nov 2018

Lu Dan, Song Jia, Sun Yizhe, Qi Fang, Liu Liang, Jin Yan, McNutt Michael A, Yin Yuxin

Abstract excerpt

Dysregulation of innate immunity accompanied by excessive interferon production contributes to autoimmune disease. However, the mechanism by which the immune response is modulated in autoimmune disorders is largely unknown. Here we identified loss-of-function mutations of OTUD1 associated with multiple autoimmune diseases. Under inflammatory conditions, inducible OTUD1 acts as an immune checkpoint and blocks...

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Source

Identifiers

PMID: 30100102
DOI: 10.1016/j.jaut.2018.07.019

Genes

OTUD1
FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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