Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Superoxide overproduction and kidney fibrosis: a new animal model.

Einstein (Sao Paulo, Brazil) - 1 Jan 2000

Guimarães-Souza Nadia Karina, Yamaleyeva Liliya Marsovna, Lu Baisong, Ramos Ana Claudia Mallet de Souza, Bishop Colin Edward, Andersson Karl Erik

Abstract excerpt

OBJECTIVE: To establish whether the mutation in the Immp2L gene induces renal fibrosis and whether aging exacerbates renal morphology in mice. METHODS: Female mutant mice with mutation in the inner mitochondrial membrane peptidase 2-like protein at 3 and 18 months of age were used. Renal fibrosis was analyzed using classic fibrosis score, Masson's trichrome staining, and analysis of profibrotic markers using real...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Creatinine
Share to Endopeptidases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Erythropoietin

Share to Fibrosis

Share to Matrix Metalloproteinase 9

Share to Renal Insufficiency, Chronic

Share to Superoxide Dismutase-1

Share to Superoxides

Source

Open in PubMed Open full text

Identifiers

PMID: 25993073
DOI: 10.1590/S1679-45082015AO3179
PMCID: PMC4977594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Superoxide overproduction and kidney fibrosis: a new animal model.PMID 25993073Read ↗

Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal.Semantic proximity Read ↗

Oxidative stress is involved in age-dependent spermatogenic damage of Immp2l mutant mice.Semantic proximity Read ↗

Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction.Semantic proximity Read ↗

Bladder dysfunction in a new mutant mouse model with increased superoxide--lack of nitric oxide?Semantic proximity Read ↗

Oxidative Injury is a Common Consequence of BMPR2 MutationsSemantic proximity Read ↗

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue.Semantic proximity Read ↗

The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment.Semantic proximity Read ↗

Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2.Semantic proximity Read ↗

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes.Semantic proximity Read ↗

Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice.Semantic proximity Read ↗

Proteomic Profiling of Aging in Glomeruli of Mice by using Two-Dimensional Differential Gel ElectrophoresisSemantic proximity Read ↗

MRL/MpJ mice show unique pathological features after experimental kidney injury.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.