Article
Genetic factors influencing the risk of multiple myeloma bone disease.
Leukemia - 1 Apr 2016
Johnson D C, Weinhold N, Mitchell J, Chen B, Stephens O W, Försti A, Nickel J, Kaiser M, Gregory W A, Cairns D, Jackson G H, Hoffmann P, Noethen M M, Hillengass J, Bertsch U, Barlogie B, Davis F E, Hemminki K, Goldschmidt H, Houlston R S, Morgan G J
Abstract excerpt
A major complication of multiple myeloma (MM) is the development of osteolytic lesions, fractures and bone pain. To identify genetic variants influencing the development of MM bone disease (MBD), we analyzed MM patients of European ancestry (totaling 3774), which had been radiologically surveyed for MBD. Each patient had been genotyped for ~6 00 000 single-nucleotide polymorphisms with genotypes for six million...
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