Article
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
Nature genetics - 1 Oct 2013
Chubb Daniel, Weinhold Niels, Broderick Peter, Chen Bowang, Johnson David C, Försti Asta, Vijayakrishnan Jayaram, Migliorini Gabriele, Dobbins Sara E, Holroyd Amy, Hose Dirk, Walker Brian A, Davies Faith E, Gregory Walter A, Jackson Graham H, Irving Julie A, Pratt Guy, Fegan Chris, Fenton James Al, Neben Kai, Hoffmann Per, Nöthen Markus M, Mühleisen Thomas W, Eisele Lewin, Ross Fiona M, Straka Christian, Einsele Hermann, Langer Christian, Dörner Elisabeth, Allan James M, Jauch Anna, Morgan Gareth J, Hemminki Kari, Houlston Richard S, Goldschmidt Hartmut
Abstract excerpt
To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P =...