Article
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.
Nature communications - 1 Jul 2016
Mitchell Jonathan S, Li Ni, Weinhold Niels, Försti Asta, Ali Mina, van Duin Mark, Thorleifsson Gudmar, Johnson David C, Chen Bowang, Halvarsson Britt-Marie, Gudbjartsson Daniel F, Kuiper Rowan, Stephens Owen W, Bertsch Uta, Broderick Peter, Campo Chiara, Einsele Hermann, Gregory Walter A, Gullberg Urban, Henrion Marc, Hillengass Jens, Hoffmann Per, Jackson Graham H, Johnsson Ellinor, Jöud Magnus, Kristinsson Sigurður Y, Lenhoff Stig, Lenive Oleg, Mellqvist Ulf-Henrik, Migliorini Gabriele, Nahi Hareth, Nelander Sven, Nickel Jolanta, Nöthen Markus M, Rafnar Thorunn, Ross Fiona M, da Silva Filho Miguel Inacio, Swaminathan Bhairavi, Thomsen Hauke, Turesson Ingemar, Vangsted Annette, Vogel Ulla, Waage Anders, Walker Brian A, Wihlborg Anna-Karin, Broyl Annemiek, Davies Faith E, Thorsteinsdottir Unnur, Langer Christian, Hansson Markus, Kaiser Martin, Sonneveld Pieter, Stefansson Kari, Morgan Gareth J, Goldschmidt Hartmut, Hemminki Kari, Nilsson Björn, Houlston Richard S
Abstract excerpt
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk...
Topics
- Adaptor Proteins, Signal Transducing
- Autophagy-Related Protein 5
- Case-Control Studies