Article
Deciphering the genetics and mechanisms of predisposition to multiple myeloma.
Nature communications - 5 Aug 2024
Went Molly, Duran-Lozano Laura, Halldorsson Gisli H, Gunnell Andrea, Ugidos-Damboriena Nerea, Law Philip, Ekdahl Ludvig, Sud Amit, Thorleifsson Gudmar, Thodberg Malte, Olafsdottir Thorunn, Lamarca-Arrizabalaga Antton, Cafaro Caterina, Niroula Abhishek, Ajore Ram, Lopez de Lapuente Portilla Aitzkoa, Ali Zain, Pertesi Maroulio, Goldschmidt Hartmut, Stefansdottir Lilja, Kristinsson Sigurdur Y, Stacey Simon N, Love Thorvardur J, Rognvaldsson Saemundur, Hajek Roman, Vodicka Pavel, Pettersson-Kymmer Ulrika, Späth Florentin, Schinke Carolina, Van Rhee Frits, Sulem Patrick, Ferkingstad Egil, Hjorleifsson Eldjarn Grimur, Mellqvist Ulf-Henrik, Jonsdottir Ingileif, Morgan Gareth, Sonneveld Pieter, Waage Anders, Weinhold Niels, Thomsen Hauke, Försti Asta, Hansson Markus, Juul-Vangsted Annette, Thorsteinsdottir Unnur, Hemminki Kari, Kaiser Martin, Rafnar Thorunn, Stefansson Kari, Houlston Richard, Nilsson Björn
Abstract excerpt
Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a substantial heritable component, but the underlying mechanisms remain unclear. Here, in a genome-wide association study totaling 10,906 cases and 366,221 controls, we identify 35 MM risk loci, 12 of which are novel. Through functional fine-mapping and Mendelian randomization, we uncover two causal mechanisms for...
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