Article
Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance.
Blood advances - 23 Jun 2020
Clay-Gilmour Alyssa I, Hildebrandt Michelle A T, Brown Elizabeth E, Hofmann Jonathan N, Spinelli John J, Giles Graham G, Cozen Wendy, Bhatti Parveen, Wu Xifeng, Waller Rosalie G, Belachew Alem A, Robinson Dennis P, Norman Aaron D, Sinnwell Jason P, Berndt Sonja I, Rajkumar S Vincent, Kumar Shaji K, Chanock Stephen J, Machiela Mitchell J, Milne Roger L, Slager Susan L, Camp Nicola J, Ziv Elad, Vachon Celine M
Abstract excerpt
So far, 23 germline susceptibility loci have been associated with multiple myeloma (MM) risk. It is unclear whether the genetic variation associated with MM susceptibility also predisposes to its precursor, monoclonal gammopathy of undetermined significance (MGUS). Leveraging 2434 MM cases, 754 MGUS cases, and 2 independent sets of controls (2567/879), we investigated potential shared genetic susceptibility of MM...
Topics
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Monoclonal Gammopathy of Undetermined Significance
- Multiple Myeloma
- Odds Ratio