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Article

TERT promoter mutations and long telomere length predict poor survival and radiotherapy resistance in gliomas.

Oncotarget - 23 Feb 2016

Gao Ke, Li Gang, Qu Yiping, Wang Maode, Cui Bo, Ji Meiju, Shi Bingyin, Hou Peng

Abstract excerpt

Increasing evidences have implicated somatic gain-of-function mutations at the telomerase reverse transcriptase (TERT) promoter as one of the major mechanisms that promote transcriptional activation of TERT and subsequently maintain telomere length in human cancers including glioma. To investigate the prognostic value of these mutations and telomere length, individually and their coexistence, in gliomas, we...

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Share to Glioma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26556853
DOI: 10.18632/oncotarget.6007
PMCID: PMC4890999

Genes

TERT
IDH1
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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