SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways

Abstract excerpt

Significance Although the host protein SAMHD1 has been studied as a restriction factor to inhibit retroviral infection, it is unknown whether and how SAMHD1 regulates antiviral innate immune responses. Using SAMHD1 -silenced human monocytic cell lines and primary macrophages, and primary splenocytes from SAMHD1 -knockout mice, we revealed new functions and mechanisms of SAMHD1-mediated negative regulation of...

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