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Article

Restriction of diverse retroviruses by SAMHD1

5 Mar 2013

Abstract excerpt

BACKGROUND: SAMHD1 is a triphosphohydrolase that restricts the replication of HIV-1 and SIV in myeloid cells. In macrophages and dendritic cells, SAMHD1 restricts virus replication by diminishing the deoxynucleotide triphosphate pool to a level below that which supports lentiviral reverse transcription. HIV-2 and related SIVs encode the accessory protein Vpx to induce the proteasomal degradation of SAMHD1...

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PMID: 23497255
DOI: 10.1186/1742-4690-10-26

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