Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts.

doi:10.1038/ncomms10192

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts.

Nature communications - 15 Dec 2015

Fasanelli Francesca, Baglietto Laura, Ponzi Erica, Guida Florence, Campanella Gianluca, Johansson Mattias, Grankvist Kjell, Johansson Mikael, Assumma Manuela Bianca, Naccarati Alessio, Chadeau-Hyam Marc, Ala Ugo, Faltus Christian, Kaaks Rudolf, Risch Angela, De Stavola Bianca, Hodge Allison, Giles Graham G, Southey Melissa C, Relton Caroline L, Haycock Philip C, Lund Eiliv, Polidoro Silvia, Sandanger Torkjel M, Severi Gianluca, Vineis Paolo

Abstract excerpt

DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case-control pairs in the NOWAC cohort, we observe that the most significant associations with lung cancer risk are for cg05575921 in AHRR (OR for 1 s.d.=0.37, 95% CI:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to CpG Islands

Share to Gene Expression Regulation

Share to Genetic Predisposition to Disease

Share to Lung Neoplasms

Share to Odds Ratio

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 26667048
DOI: 10.1038/ncomms10192
PMCID: PMC4682166

Genes

AHRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts.PMID 26667048Read ↗

DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk.Semantic proximity Read ↗

AHRR (cg05575921) hypomethylation marks smoking behaviour, morbidity and mortality.Semantic proximity Read ↗

Smoking-associated DNA methylation markers predict lung cancer incidence.Semantic proximity Read ↗

Epigenome-wide association study of smoking and DNA methylation in non-small cell lung neoplasms.Semantic proximity Read ↗

Identification of novel epigenetic abnormalities as sputum biomarkers for lung cancer risk among smokers and COPD patientsSemantic proximity Read ↗

AHRR methylation in heavy smokers: associations with smoking, lung cancer risk, and lung cancer mortality.Semantic proximity Read ↗

Lung DNA Methylation in Chronic Obstructive Pulmonary Disease: Relationship with Smoking Status and Airflow Limitation SeveritySemantic proximity Read ↗

From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes.Semantic proximity Read ↗

Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases.Semantic proximity Read ↗

DNA methylation is associated with lung function in never smokersSemantic proximity Read ↗

The impact of genetic variation and cigarette smoke on DNA methylation in current and former smokers from the COPDGene study.Semantic proximity Read ↗

From tobacco smoking to mutational signature: the role of epigenetic changes in human cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.