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<i>SALL3</i> mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss

2023-06-26

Abstract excerpt

Human pluripotent stem cell (hPSC) cultures are prone to genetic drift, as cells that have acquired specific genetic abnormalities experience a selective advantage in vitro. These abnormalities are highly recurrent in hPSC lines worldwide, but currently their functional consequences in differentiating cells are scarcely described. An accurate assessment of the risk associated with these genetic variants in both re...

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Literature Corpus work
d5b21bd5-920e-5c60-91d9-f2efc12dfe86
DOI
10.1101/2023.06.26.546513
Open publication

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<i>SALL3</i> mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q lossDOI 10.1101/2023.06.26.546513
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