Article

SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss

2023-07-28

Abstract excerpt

<title>Abstract</title> Human pluripotent stem cell (hPSC) cultures are prone to genetic drift, as cells that have acquired specific genetic abnormalities experience a selective advantage in vitro. These abnormalities are highly recurrent in hPSC lines worldwide, but currently their functional consequences in differentiating cells are scarcely described. An accurate assessment of the risk associated with these...

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Literature Corpus work: fb4f42be-c1f2-5223-b48f-66477a43e809
DOI: 10.21203/rs.3.rs-3100381/v1

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