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Article

High-Magnitude and/or High-Frequency Mechanical Strain Promotes Peripapillary Scleral Myofibroblast Differentiation.

Investigative ophthalmology & visual science - 1 Dec 2015

Qu Jing, Chen Huaping, Zhu Lanyan, Ambalavanan Namasivayam, Girkin Christopher A, Murphy-Ullrich Joanne E, Downs J Crawford, Zhou Yong

Abstract excerpt

PURPOSE: To determine the effects of altered mechanical strain on human peripapillary scleral (ppSc) fibroblast-to-myofibroblast differentiation. METHODS: Eight human ppSc fibroblast cultures were isolated from three paired eyes and two unilateral eyes of five donors using an explant approach. Human ppSc fibroblast isolates were subjected to 1% and 4% cyclic strain at 0.05 to 5 Hz for 24 hours. Levels of α smooth...

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Identifiers

PMID: 26658503
DOI: 10.1167/iovs.15-17848
PMCID: PMC4682490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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