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Article

Mirna Expression in Glaucomatous and TGFβ2 Treated Lamina Cribrosa Cells

8 Jun 2021

Abstract excerpt

Glaucoma is a group of optic neuropathies that leads to irreversible vision loss. The optic nerve head (ONH) is the site of initial optic nerve damage in glaucoma. ONH-derived lamina cribrosa (LC) cells synthesize extracellular matrix (ECM) proteins; however, these cells are adversely affected in glaucoma and cause detrimental changes to the ONH. LC cells respond to mechanical strain by increasing the profibrotic...

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PMID: 34201109
DOI: 10.3390/ijms22126178

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