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Article

Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells.

Investigative ophthalmology & visual science - 1 Feb 2018

Liu Baiyun, Kilpatrick Jason I, Lukasz Bartlomiej, Jarvis Suzanne P, McDonnell Fiona, Wallace Deborah M, Clark Abbot F, O'Brien Colm J

Abstract excerpt

Purpose: Alteration in the extracellular matrix (ECM) of the optic nerve head (ONH) causes lamina cribrosa (LC) fibrosis and affects the mechanical integrity of the ONH. Increased ECM tissue stiffness drives myofibroblast activation leading to tissue fibrosis throughout the body. Here using primary human LC cells, we investigate the effect of substrate stiffness on profibrotic changes, which might be a key...

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Identifiers

PMID: 29392327
DOI: 10.1167/iovs.17-22400

Genes

AFM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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