Article

Compression injury regulates astrocyte morphology, metabolic function, and extracellular matrix modification in a 3D hydrogel

2025-06-25

Abstract excerpt

In glaucoma, the optic nerve head (ONH) is exposed to increased biomechanical strain, impacting the resident astrocytes that maintain neural homeostasis. During disease progression astrocytes exhibit morphologic and metabolic shifts; however, the specific impact of glaucoma-related biomechanical strains on astrocyte behavior remains poorly understood. To address this, we used our previously established 3D cell-enc...

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Literature Corpus work: 6460f4c7-f8e3-5ab3-a225-576fb49350fd
DOI: 10.1101/2025.06.20.660800

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