Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanical Strain Induces Distinct Human Scleral Fibroblast Lineages: Differential Roles in Cell Proliferation, Apoptosis, Migration, and Differentiation

11 May 2018

Abstract excerpt

Purpose: The purpose of this study was to explore the effect of mechanical strain on human scleral fibroblasts (HSFs) and compare cell behaviors of HSFs from distinct regions. Methods: Primary HSFs were cultivated using a digestive protocol. Cells were seeded on collagen I-coated Bioflex plates, and a FX-5000 tension system was used to perform biaxial mechanical strain in vitro. We applied 10%, 0.5-Hz mechanical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Mechanics and Interactions
Share to Corneal Surgery and Treatments
Share to Tendon Structure and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29847646
DOI: 10.1167/iovs.18-23855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanical Strain Induces Distinct Human Scleral Fibroblast Lineages: Differential Roles in Cell Proliferation, Apoptosis, Migration, and DifferentiationPMID 29847646Read ↗

High-Magnitude and/or High-Frequency Mechanical Strain Promotes Peripapillary Scleral Myofibroblast Differentiation.Semantic proximity Read ↗

Changes in gene expression in response to mechanical strain in human scleral fibroblastsSemantic proximity Read ↗

Mechanical Strain Regulates Myofibroblast Differentiation of Human Scleral Fibroblasts by YAPSemantic proximity Read ↗

Biomechanical strain induces elastin and collagen production in human pluripotent stem cell-derived vascular smooth muscle cellsSemantic proximity Read ↗

Human Sclera Maintains Common Characteristics with Cartilage throughout EvolutionSemantic proximity Read ↗

Mechanical strain applied to human fibroblasts differentially regulates skeletal myoblast differentiationSemantic proximity Read ↗

Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells.Semantic proximity Read ↗

Substrate stiffness controls the cell cycle of human mesenchymal stem cells via cellular tractionSemantic proximity Read ↗

Mechanical force modulates scleraxis expression in bioartificial tendons.Semantic proximity Read ↗

Cultured myofibroblasts display a specific phenotype that differentiates them from fibroblasts and smooth muscle cells.Semantic proximity Read ↗

Force and scleraxis synergistically promote the commitment of human ES cells derived MSCs to tenocytesSemantic proximity Read ↗

Mechanical stimuli differentially control stem cell behavior: morphology, proliferation, and differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.