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Biomechanical strain induces elastin and collagen production in human pluripotent stem cell-derived vascular smooth muscle cells

25 Jun 2015

Abstract excerpt

Blood vessels are subjected to numerous biomechanical forces that work harmoniously but, when unbalanced because of vascular smooth muscle cell (vSMC) dysfunction, can trigger a wide range of ailments such as cerebrovascular, peripheral artery, and coronary artery diseases. Human pluripotent stem cells (hPSCs) serve as useful therapeutic tools that may help provide insight on the effect that such biomechanical...

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PMID: 26108668
DOI: 10.1152/ajpcell.00366.2014

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