Article
Derivation of poly-methylomic profile scores for schizophrenia.
Progress in neuro-psychopharmacology & biological psychiatry - 13 Jul 2020
Watkeys Oliver J, Cohen-Woods Sarah, Quidé Yann, Cairns Murray J, Overs Bronwyn, Fullerton Janice M, Green Melissa J
Abstract excerpt
Schizophrenia and bipolar disorder share biological features and environmental risk factors that may be associated with altered DNA methylation. In this study we sought to: 1) construct a novel 'Poly-Methylomic Profile Score (PMPS)' by transforming schizophrenia-associated epigenome-wide methylation from a previously published epigenome-wide association study (EWAS) into a single quantitative metric; and 2)...
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