Article
Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex.
Neurobiology of aging - 1 May 2020
Pishva Ehsan, Creese Byron, Smith Adam R, Viechtbauer Wolfgang, Proitsi Petroula, van den Hove Daniel L A, Ballard Clive, Mill Jonathan, Lunnon Katie
Abstract excerpt
Psychotic symptoms are a common and debilitating feature of Alzheimer's disease (AD) and are associated with a more rapid course of decline. Current evidence from postmortem and neuroimaging studies implicates frontal, temporal, and parietal lobes, with reported disruptions in monoaminergic pathways. However, the molecular mechanisms underlying this remain unclear. In the present study, we investigated methylomic...
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