Article
Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.
Cancer discovery - 1 Jan 2018
Zhang Xiaoyang, Choi Peter S, Francis Joshua M, Gao Galen F, Campbell Joshua D, Ramachandran Aruna, Mitsuishi Yoichiro, Ha Gavin, Shih Juliann, Vazquez Francisca, Tsherniak Aviad, Taylor Alison M, Zhou Jin, Wu Zhong, Berger Ashton C, Giannakis Marios, Hahn William C, Cherniack Andrew D, Meyerson Matthew
Abstract excerpt
The Krüppel-like family of transcription factors plays critical roles in human development and is associated with cancer pathogenesis. Krüppel-like factor 5 gene (KLF5) has been shown to promote cancer cell proliferation and tumorigenesis and to be genomically amplified in cancer cells. We recently reported that the KLF5 gene is also subject to other types of somatic coding and noncoding genomic alterations in...
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