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Article

Genetic variants in PI3K/AKT pathway are associated with severe radiation pneumonitis in lung cancer patients treated with radiation therapy.

Cancer medicine - 1 Jan 2016

Tang Yang, Liu Bo, Li Jing, Wu Huanlei, Yang Ju, Zhou Xiao, Yi Mingxiao, Li Qianxia, Yu Shiying, Yuan Xianglin

Abstract excerpt

PI3K/AKT pathway plays important roles in inflammatory and fibrotic diseases while its connection to radiation pneumonitis (RP) is unclear. In this study, we explored the associations of genetic variants in PI3K/AKT pathway with RP in lung cancer patients with radiotherapy. Two hundred and sixty one lung cancer patients with radiotherapy were included in this prospective study (NCT02490319) and genotyped by...

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Identifiers

PMID: 26645682
DOI: 10.1002/cam4.564
PMCID: PMC4708901

Genes

AKT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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