Article
Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy.
Radiation oncology (London, England) - 8 Jan 2020
Tang Yang, Yang Li, Qin Wan, Yi Min' Xiao, Liu Bo, Yuan Xiang'Lin
Abstract excerpt
BACKGROUND: Homeodomain-interacting protein kinase 2 (HIPK2) has increasingly drawn attention as recent researches demonstrated its unique role in the regulation of multiple fundamental processes such as apoptosis, proliferation and DNA damage repair. Most importantly, HIPK2 was shown to play regulatory role in inflammation and influence the phenotype and activity of fibroblasts. In this study, we aimed to...
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