Article
Association between ATM gene polymorphisms, lung cancer susceptibility and radiation-induced pneumonitis: a meta-analysis.
BMC pulmonary medicine - 15 Dec 2017
Yan Zhipeng, Tong Xiang, Ma Yao, Liu Sitong, Yang Lingjing, Yang Xin, Yang Xue, Bai Min, Fan Hong
Abstract excerpt
BACKGROUND: Previous studies have suggested that DNA double-strand break (DSB) repair is an important protective pathway after damage. The ataxia telangiectasia mutated (ATM) gene plays an important role in the DNA DSB repair pathway. DNA damage is a major cytotoxic effect that can be caused by radiation, and the ability to repair DNA after damage varies among different tissues. Impaired DNA repair pathways are...
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