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Article

Genetic variants in the plasminogen activator inhibitor-1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients.

Cancer medicine - 1 Mar 2017

Liu Bo, Tang Yang, Yi Minxiao, Liu Qingxu, Xiong Huihua, Hu Guangyuan, Yuan Xianglin

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) plays a crucial role in the process of lung injury, although its association with radiation pneumonitis (RP) is unclear. We hypothesized that genetic variants in PAI-1 may influence the risk of RP. In this study, 169 lung cancer patients were genotyped for six single-nucleotide polymorphisms in PAI-1 using the Sequenom MassARRAY system. The risk of RP was evaluated by Cox...

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PMID: 28211612
DOI: 10.1002/cam4.1011
PMCID: PMC5345627

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