Article
Apoptotic Platelet Events Are Not Observed in Severe von Willebrand Disease-Type 2B Mutation p.V1316M.
PloS one - 1 Jan 2015
Berrou Eliane, Kauskot Alexandre, Adam Frédéric, Harel Amélie, Legendre Paulette, Lavenu Bombled Cécile, Rothschild Chantal, Prevost Nicolas, Christophe Olivier D, Lenting Peter J, Denis Cécile V, Rosa Jean-Philippe, Bryckaert Marijke
Abstract excerpt
Thrombocytopenia and increased platelet clearance observed in von Willebrand disease-type 2B (VWD-2B) may be explained by platelet apoptosis triggered by the constitutive binding of VWF to its receptor, glycoprotein Ib (GPIb). Apoptosis was assessed in platelets from two patients with a severe VWD-2B mutation VWF/p.V1316M and from mice transiently expressing VWF/p.V1316M. We now report that the VWD-2B mutation...
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