Article

Plasmin-mediated cleavage of GPIbα contributes to breakdown of platelet-von Willebrand factor complexes

2026-03-25

Abstract excerpt

Von Willebrand factor (VWF) is an essential contributor to hemostasis through its interaction with the platelet glycoprotein (GP) Ibα receptor. VWF is cleaved by ADAMTS13 to limit its prothrombotic properties. Failure to do so can result in platelet-VWF complexes that occlude the microcirculation, as seen in thrombotic thrombocytopenic purpura (TTP). In this setting, plasmin becomes active to cleave VWF, forming a...

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Literature Corpus work: 4cbf8bcd-9f9d-5545-bbea-77e1056907ce
DOI: 10.64898/2026.03.24.713874

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