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Article

Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1).

British journal of haematology - 1 Sept 2016

Delbridge Alex R D, Chappaz Stephane, Ritchie Matthew E, Kile Benjamin T, Strasser Andreas, Grabow Stephanie

Abstract excerpt

Apoptosis is required to maintain tissue homeostasis in multicellular organisms. Platelets, the anucleate cells that are essential for blood clotting, are a prime example. Their brief life span in the circulation is regulated by the intrinsic apoptosis pathway. Pro-survival BCL-XL (also termed BCL2L1) is essential for platelet viability. It functions to restrain the pro-apoptotic BCL-2 family members BAK (also...

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Source

Identifiers

PMID: 27221652
DOI: 10.1111/bjh.14155

Genes

BAX
BBC3
BAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1).PMID 27221652Read ↗

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Apoptotic Processes in Megakaryocytes and PlateletsSemantic proximity Read ↗

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