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Article

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

21 Jun 2014

Abstract excerpt

Thrombosis is common in patients suffering from myeloproliferative neoplasm (MPN), whereas bleeding is less frequent. JAK2(V617F), the main mutation involved in MPN, is considered as a risk factor for thrombosis, although the direct link between the mutation and hemostatic disorders is not strictly established. We investigated this question using conditional JAK2(V617F) knock-in mice with constitutive and...

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PMID: 24951423
DOI: 10.1182/blood-2013-10-530832

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