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Article

Anti‐Beta‐2 Glycoprotein I Antibodies Affect Bcl‐2 and Bax Trophoblast Expression without Evidence of Apoptosis

1 Jun 2006

Abstract excerpt

Antiphospholipid antibodies (aPLs) reacting with beta-2 glycoprotein I (beta2GPI) have been associated with recurrent fetal loss and pregnancy complications. The aim of the study was to investigate whether aPLs with anti-beta2GPI specificity induce apoptosis of human trophoblasts in vitro. To this end, human anti-beta2GPI monoclonal IgM derived from a patient with antiphospholipid syndrome and a human irrelevant...

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PMID: 16855163
DOI: 10.1196/annals.1351.034

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