Article
Apoptotic versus procoagulant platelets: similar "necrotic" phenotype and procoagulant activity in vitro, but distinct adhesive protein composition.
Thrombosis research - 1 Jul 2026
Podoplelova N A, Obydennyi S I, Ignatova A A, Soloveva P A, Chabin I A, Dasgupta A K Garzon, Filkova A A, Starostin N N, Sokolov A V, Kireev I I, Balashova E N, Trakhtman P E, Novichkova G A, Sveshnikova A N, Panteleev M A
Abstract excerpt
Platelets can undergo at least two distinct types of regulated cell death, apoptosis and mPTP-driven necrosis. Apoptosis is believed to be responsible for platelet clearance, while strong platelet activation by physiological agonists leads to necrosis, producing procoagulant platelet remnants that are essential for blood coagulation during thrombosis and hemostasis. To thoroughly compare morphological and...
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