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Article

Structure-dynamic basis of splicing-dependent regulation in tissue-specific variants of the sodium-calcium exchanger.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2016

Lee Su Youn, Giladi Moshe, Bohbot Hilla, Hiller Reuben, Chung Ka Young, Khananshvili Daniel

Abstract excerpt

Tissue-specific splice variants of Na(+)/Ca(2+) exchangers contain 2 Ca(2+)-binding regulatory domains (CBDs), CBD1 and CBD2. Ca(2+) interaction with CBD1 activates sodium-calcium exchangers (NCXs), and Ca(2+) binding to CBD2 alleviates Na(+)-dependent inactivation. A combination of mutually exclusive (A, B) and cassette (C-F) exons in CBD2 raises functionally diverse splice variants through unknown mechanisms....

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Identifiers

PMID: 26644350
DOI: 10.1096/fj.15-282251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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