Article
The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B.
Gut - 1 Sept 2016
Hu Hui-Han, Liu Jessica, Lin Yu-Ling, Luo Wun-Sheng, Chu Yu-Ju, Chang Chia-Lin, Jen Chin-Lan, Lee Mei-Hsuan, Lu Sheng-Nan, Wang Li-Yu, You San-Lin, Yang Hwai-I, Chen Chien-Jen
Abstract excerpt
OBJECTIVE: The sodium taurocholate co-transporting polypeptide (NTCP), encoded by SLC10A1, was recently identified as a receptor for HBV. We assessed the association of the p.Ser267Phe variant (rs2296651) with chronic hepatitis B (CHB) serostatus, cirrhosis and hepatocellular carcinoma (HCC) in patients with CHB. DESIGN: The variant was genotyped in 3801 patients with CHB and 3801 matched hepatitis B surface...
Topics
- Adult
- Carcinoma, Hepatocellular
- Disease Progression
- Female
- Genetic Predisposition to Disease
- Hepatitis B Surface Antigens
- Hepatitis B virus