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Article

Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2007

Samy Eileen T, Meyer Claas A, Caplazi Patrick, Langrish Claire L, Lora Jose M, Bluethmann Horst, Peng Stanford L

Abstract excerpt

Sphingosine kinase (Sphk) phosphorylates sphingosine into sphingosine-1-phosphate (S1P), but its recently identified isoform Sphk2 has been suggested to have distinct subcellular localization and substrate specificity. We demonstrate here that, surprisingly, Sphk2(-/-) CD4(+) T cells exhibit a hyperactivated phenotype with significantly enhanced proliferation and cytokine secretion in response to IL-2 as well as...

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Identifiers

PMID: 17947634
DOI: 10.4049/jimmunol.179.9.5644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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