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Article

Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation.

The Journal of biological chemistry - 13 Apr 2007

Zeidan Youssef H, Hannun Yusuf A

Abstract excerpt

Although important for cellular stress signaling pathways, the molecular mechanisms of acid sphingomyelinase (ASMase) activation remain poorly understood. Previous studies showed that treatment of MCF-7 mammary carcinoma cells with the potent protein kinase C (PKC) agonist, phorbol 12-myristate 13-acetate (PMA), induces a transient drop in sphingomyelin concomitant with an increase in cellular ceramide levels...

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Identifiers

PMID: 17303575
DOI: 10.1074/jbc.M609424200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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