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Genetic variant in DNA repair gene GTF2H4 is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium.

Carcinogenesis - 1 Sept 2016

Wang Meilin, Liu Hongliang, Liu Zhensheng, Yi Xiaohua, Bickeboller Heike, Hung Rayjean J, Brennan Paul, Landi Maria Teresa, Caporaso Neil, Christiani David C, Doherty Jennifer Anne, Amos Christopher I, Wei Qingyi

Abstract excerpt

DNA repair pathways maintain genomic integrity and stability, and dysfunction of DNA repair leads to cancer. We hypothesize that functional genetic variants in DNA repair genes are associated with risk of lung cancer. We performed a large-scale meta-analysis of 123,371 single nucleotide polymorphisms (SNPs) in 169 DNA repair genes obtained from six previously published genome-wide association studies (GWASs) of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27288692
DOI: 10.1093/carcin/bgw070
PMCID: PMC5008248

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MSH5

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