Article
Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations.
Human molecular genetics - 15 Mar 2008
Haiman Christopher A, Hsu Chris, de Bakker Paul I W, Frasco Melissa, Sheng Xin, Van Den Berg David, Casagrande John T, Kolonel Laurence N, Le Marchand Loic, Hankinson Susan E, Han Jiali, Dunning Alison M, Pooley Karen A, Freedman Matthew L, Hunter David J, Wu Anna H, Stram Daniel O, Henderson Brian E
Abstract excerpt
Genetic association studies of multiple populations investigate a wider range of risk alleles than studies of a single ethnic group. In this study, we developed a multiethnic tagging strategy, exploiting differences in linkage disequilibrium (LD) structure between populations, to comprehensively capture common genetic variation across 60 genes spanning multiple DNA repair pathways, in five racial/ethnic...
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