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Article

Assessing SNP-SNP interactions among DNA repair, modification and metabolism related pathway genes in breast cancer susceptibility.

PloS one - 1 Jan 2014

Sapkota Yadav, Mackey John R, Lai Raymond, Franco-Villalobos Conrado, Lupichuk Sasha, Robson Paula J, Kopciuk Karen, Cass Carol E, Yasui Yutaka, Damaraju Sambasivarao

Abstract excerpt

Genome-wide association studies (GWASs) have identified low-penetrance common variants (i.e., single nucleotide polymorphisms, SNPs) associated with breast cancer susceptibility. Although GWASs are primarily focused on single-locus effects, gene-gene interactions (i.e., epistasis) are also assumed to contribute to the genetic risks for complex diseases including breast cancer. While it has been hypothesized that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23755158
DOI: 10.1371/journal.pone.0064896
PMCID: PMC3670937

Genes

BRCA2
MDM2
MLH1
APEX1
MBD2
RPAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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