Article

Deep Insertion, Deletion, and Missense Mutation Libraries for Exploring Protein Variation in Evolution, Disease, and Biology

2022-07-27

Abstract excerpt

Insertions and deletions (indels) are a major source of genetic variation in evolution and the cause of nearly 30% of Mendelian disease. Despite their importance, indels are left out of nearly every systematic mutational scan to date due to technical challenges associated with making indel-containing libraries, limiting our understanding of indels in disease, biology, and evolution. Here we present a library gener...

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Literature Corpus work: 0be65473-5c53-5ed2-8e92-e9dd6139555e
DOI: 10.1101/2022.07.26.501589

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