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Article

Activation of human VPS4A by ESCRT-III proteins reveals ability of substrates to relieve enzyme autoinhibition.

The Journal of biological chemistry - 12 Nov 2010

Merrill Samuel A, Hanson Phyllis I

Abstract excerpt

VPS4 proteins are AAA(+) ATPases required to form multivesicular bodies, release viral particles, and complete cytokinesis. They act by disassembling ESCRT-III heteropolymers during or after their proposed function in membrane scission. Here we show that purified human VPS4A is essentially inactive but can be stimulated to hydrolyze ATP by ESCRT-III proteins in a reaction that requires both their previously...

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Source

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Identifiers

PMID: 20805225
DOI: 10.1074/jbc.M110.126318
PMCID: PMC2975166

Genes

CHMP3
CHMP5
CHMP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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