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The good and the bad faces of STAT1 in solid tumours

26 Nov 2015

Abstract excerpt

Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase (JAK)/STAT signalling cascade and is best known for its essential role in mediating responses to all types of interferons (IFN). STAT1 regulates a variety of cellular processes, such as antimicrobial activities, cell proliferation and cell death. It exerts important immune modulatory activities both in the innate and the...

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PMID: 26631912
DOI: 10.1016/j.cyto.2015.11.011

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