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Article

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

1 Jul 2015

Abstract excerpt

Aberrant activation of intracellular signalling pathways confers malignant properties on cancer cells. Targeting intracellular signalling pathways has been a productive strategy for drug development, with several drugs acting on signalling pathways already in use and more continually being developed. The JAK/STAT signalling pathway provides an example of this paradigm in haematological malignancies, with the...

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PMID: 26151455
DOI: 10.1038/bjc.2015.233

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