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Article

The JAK/STAT3 axis: A comprehensive drug target for solid malignancies.

Seminars in cancer biology - 1 Aug 2017

Huynh Jennifer, Etemadi Nima, Hollande Frédéric, Ernst Matthias, Buchert Michael

Abstract excerpt

Intercellular communication between tumor cells, immune cells and the stroma characterises the tumor microenvironment, which is instrumental for establishing the ecological niche that fosters tumor growth and metastasis. While tumor cell intrinsic STAT3 signaling provides a crucial axis to support cell proliferation and survival, it also regulates many activities of the non-transformed cells that collectively...

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Source

Identifiers

PMID: 28647610
DOI: 10.1016/j.semcancer.2017.06.001

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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