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Article

STAT proteins: From normal control of cellular events to tumorigenesis

31 Jul 2003

Abstract excerpt

Signal transducers and activators of transcription (STAT) proteins comprise a family of transcription factors latent in the cytoplasm that participate in normal cellular events, such as differentiation, proliferation, cell survival, apoptosis, and angiogenesis following cytokine, growth factor, and hormone signaling. STATs are activated by tyrosine phosphorylation, which is normally a transient and tightly...

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PMID: 14502555
DOI: 10.1002/jcp.10364

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