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Article

Identification of a Novel Pathogenic Germline KDR Variant in Melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2016

Silva Ines P, Salhi Amel, Giles Keith M, Vogelsang Matjaz, Han Sung W, Ismaili Naima, Lui Kevin P, Robinson Eric M, Wilson Melissa A, Shapiro Richard L, Pavlick Anna, Zhong Judy, Kirchhoff Tomas, Osman Iman

Abstract excerpt

PURPOSE: The application of pan-cancer next-generation sequencing panels in the clinical setting has facilitated the identification of low frequency somatic mutations and the testing of new therapies in solid tumors using the "basket trial" scheme. However, little consideration has been given to the relevance of nonsynonymous germline variants, which are likely to be uncovered in tumors and germline and which may...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26631613
DOI: 10.1158/1078-0432.CCR-15-1811
PMCID: PMC4867268

Genes

KDR
MVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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