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Article

Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2011

Glubb Dylan M, Cerri Elisa, Giese Alexandra, Zhang Wei, Mirza Osman, Thompson Emma E, Chen Peixian, Das Soma, Jassem Jacek, Rzyman Witold, Lingen Mark W, Salgia Ravi, Hirsch Fred R, Dziadziuszko Rafal, Ballmer-Hofer Kurt, Innocenti Federico

Abstract excerpt

PURPOSE: VEGF receptor 2 (VEGFR-2) plays a crucial role in mediating angiogenic endothelial cell responses via the VEGF pathway, and angiogenesis inhibitors targeting VEGFR-2 are in clinical use. As angiogenesis is a host-driven process, functional heritable variation in KDR, the gene encoding VEGFR-2, may affect VEGFR-2 function and, ultimately, the extent of tumor angiogenesis. EXPERIMENTAL DESIGN: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21712447
DOI: 10.1158/1078-0432.CCR-11-0379
PMCID: PMC3156871

Genes

KDR
MVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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