Article
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.
Nature genetics - 1 Oct 2009
Prickett Todd D, Agrawal Neena S, Wei Xiaomu, Yates Kristin E, Lin Jimmy C, Wunderlich John R, Cronin Julia C, Cruz Pedro, Rosenberg Steven A, Samuels Yardena
Abstract excerpt
Tyrosine phosphorylation is important in signaling pathways underlying tumorigenesis. We performed a mutational analysis of the protein tyrosine kinase (PTK) gene family in cutaneous metastatic melanoma. We identified 30 somatic mutations affecting the kinase domains of 19 PTKs and subsequently evaluated the entire coding regions of the genes encoding these 19 PTKs for somatic mutations in 79 melanoma samples. We...
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