Article
A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.
Molecular cancer therapeutics - 1 Apr 2012
Dutton-Regester Ken, Irwin Darryl, Hunt Priscilla, Aoude Lauren G, Tembe Varsha, Pupo Gulietta M, Lanagan Cathy, Carter Candace D, O'Connor Linda, O'Rourke Michael, Scolyer Richard A, Mann Graham J, Schmidt Christopher W, Herington Adrian, Hayward Nicholas K
Abstract excerpt
Success with molecular-based targeted drugs in the treatment of cancer has ignited extensive research efforts within the field of personalized therapeutics. However, successful application of such therapies is dependent on the presence or absence of mutations within the patient's tumor that can confer clinical efficacy or drug resistance. Building on these findings, we developed a high-throughput mutation panel...
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